Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors.

@article{Brown2006NeonicotinoidID,
  title={Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors.},
  author={Laurence A Brown and Makoto Ihara and Steven Buckingham and Kazuhiko Matsuda and David B Sattelle},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 2},
  pages={
          608-15
        }
}
Nicotinic acetylcholine receptors (nAChRs) are present in high density in insect nervous tissue and are targeted by neonicotinoid insecticides. Improved understanding of the actions of these insecticides will assist in the development of new compounds. Here, we have used whole-cell patch-clamp recording of cholinergic neurons cultured from the central nervous system of 3rd instar Drosophila larvae to examine the actions of acetylcholine (ACh) and nicotine, as well as the neonicotinoids… CONTINUE READING

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