Neonatal vitamin D status at birth at latitude 32°72′: evidence of deficiency

  title={Neonatal vitamin D status at birth at latitude 32°72′: evidence of deficiency},
  author={Laura A. Basile and S. N Taylor and Carol L. Wagner and Lakeya Quinones and Bruce W Hollis},
  journal={Journal of Perinatology},
Objective:With vitamin D deficiency as a serious public health problem, vitamin D status at birth was measured in neonates at latitude 32°72′ (southeastern United States).Study Design:In umbilical cord blood, vitamin D status, demonstrated by circulating 25-hydroxyvitamin D, was measured and related to race and season of birth.Result:The mean±standard deviation of 25-hydroxyvitamin D in 100 cord blood samples was 13.5±8.3 ng/ml for the cohort. African-American infants, with a mean±standard… 
Vitamin D Status among 4-Month-Old Infants in New England
  • A. Merewood, S. Mehta, H. Bauchner
  • Medicine
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  • 2012
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The present study shows a high prevalence of vitamin D insufficiency and deficiency in newborns with significant differences observed to be due to ethnicity, skin colour and maternal supplementation during the pregnancy.
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Vitamin D deficiency is widespread in newborn and maternal 25OHD levels above 50 nmol/l are needed to prevent vitamin D deficiency among newborn.
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There was a significant vitamin D deficiency among a cohort of women and their infants living at two diverse latitudes—Charleston, SC and Rochester, NY and conclusions about vitamin D status based on latitude alone may be faulty.
Racial variation in vitamin D cord blood concentration in white and black male neonates
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The utility of neonatal dried blood spots for the assessment of neonatal vitamin D status.
Archived DBS samples provided a valid measure of perinatal vitamin D status and identified inter-seasonal differences in per inatal 25OHD3 concentrations.
Vitamin D Needs of Preterm Infants
In this review, some of the issues surrounding vitamin D status of the neonate and the particular risks for the preterm infant are highlighted and oral vitamin D supplementation is considered as an important adjunct to dietary sources and multivitamin preparations.
Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China
The prevalence of vitamin D insufficiency was 28.24%, and birth in winter was a risk factor for vitamin DInsufficiency in hospitalized full-term neonates in Suzhou area, and the incidence of infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia in the vitamin D Insufficiency group were higher than sufficiency group (P < 0.05).
Vitamin D in the maternal–fetal–neonatal interface: clinical implications and requirements for supplementation
  • I. Marshall, R. Mehta, A. Petrova
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2013
It is believed that inconsistency in the recognition of sufficient levels of vitamin D in mothers and their infants affects the identification of adequate doses for vitamin D supplementation during pregnancy, lactation and infancy.


The endogenous pool of 1,25‐dihydroxyvitamin D3 decayed with a T of 22.5 d, indicating that vitamin D supplementation of these infants was necessary to avoid vitamin D‐deficiency.
Vitamin D deficiency and fetal growth.
Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns
A high rate of vitamin D deficiency was observed among women and their newborn infants and among infants, vitaminD deficiency was associated with greater weight and length but lower bone mass relative to body weight.
Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D.
  • B. Hollis
  • Medicine
    The Journal of nutrition
  • 2005
It has been more than 3 decades since the first assay assessing circulating 25-hydroxyvitamin D in human subjects was performed and led to the definition of "normal" nutritional vitamin D status, i.e., vitamin D sufficiency, and current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.
Vitamin D Deficiency in a Healthy Group of Mothers and Newborn Infants
Maternal vitamin D deficiency may represent an important risk factor for the development of rickets in children and a positive correlation between maternal and infant plasma 25-hydroxyvitamin D concentrations is found.
Evaluation of the total fetomaternal vitamin D relationships at term: evidence for racial differences.
The results support the concept that fetomaternal vitamin D status are intimately related and strongly suggest that fetal metabolism begins with 25-hydroxyvitamin D rather than vitamin D.
High-dose vitamin D3 supplementation in a cohort of breastfeeding mothers and their infants: a 6-month follow-up pilot study.
With limited sun exposure, an intake of 400 IU/day vitamin D(3) did not sustain circulating maternal 25(OH)D levels, and thus, supplied only extremely limited amounts of vitamin D to the nursing infant via breast milk.
Birthweight, vitamin D receptor genotype and the programming of osteoporosis.
The results suggest that genetic influences on adult bone size and mineral density may be modified by undernutrition in utero.
Dietary recommendations to meet both endocrine and autocrine needs of Vitamin D
Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994.
The high prevalence of hypovitaminosis D among African American women warrants further examination of vitamin D recommendations for these women, and the determinants ofHypov vitamin D among women should be considered when these women are advised on dietary intake and supplement use.