Neonatal ventral hippocampus lesion induces increase in nitric oxide [NO] levels which is attenuated by subchronic haloperidol treatment.

@article{NegreteDaz2010NeonatalVH,
  title={Neonatal ventral hippocampus lesion induces increase in nitric oxide [NO] levels which is attenuated by subchronic haloperidol treatment.},
  author={Jos{\'e} Vicente Negrete-D{\'i}az and Eduardo Baltazar-Gayt{\'a}n and Mar{\'i}a Elena Bringas and Rub{\'e}n Antonio V{\'a}zquez-Roque and Stephanie Newton and P Aguilar-Alonso and Bertha Alicia Leon-Chavez and Gonzalo Flores},
  journal={Synapse},
  year={2010},
  volume={64 12},
  pages={941-7}
}
Haloperidol is a potent dopamine receptor antagonist and used to treat psychotic disorders, such as schizophrenia. Recent clinical and preclinical studies demonstrated the overactivity of the nitric oxide (NO) system in schizophrenia. Neonatal ventral hippocampal (nVH) lesions in rats have been widely used as a neurodevelopmental model that mimics schizophrenia-like behaviors. Here, we investigate first whether the nVH lesion causes changes in NO levels in different limbic brain regions in… CONTINUE READING