Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation

@article{Phua2016NeonatalVA,
  title={Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation},
  author={Yu Leng Phua and Thierry Gilbert and Alexander N. Combes and Lorine Wilkinson and Melissa H. Little},
  journal={The Journal of Pathology},
  year={2016},
  volume={238}
}
Congenital medullary dysplasia with obstructive nephropathy is a common congenital disorder observed in paediatric patients and represents the foremost cause of renal failure. However, the molecular processes regulating normal papillary outgrowth during the postnatal period are unclear. In this study, transcriptional profiling of the renal medulla across postnatal development revealed enrichment of non‐canonical Wnt signalling, vascular development, and planar cell polarity genes, all of which… Expand
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