Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation

  title={Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation},
  author={Yu Leng Phua and Thierry Gilbert and Alexander N. Combes and Lorine Wilkinson and Melissa H. Little},
  journal={The Journal of Pathology},
Congenital medullary dysplasia with obstructive nephropathy is a common congenital disorder observed in paediatric patients and represents the foremost cause of renal failure. However, the molecular processes regulating normal papillary outgrowth during the postnatal period are unclear. In this study, transcriptional profiling of the renal medulla across postnatal development revealed enrichment of non‐canonical Wnt signalling, vascular development, and planar cell polarity genes, all of which… Expand
6 Citations
Proximal Tubular Development Is Impaired with Downregulation of MAPK/ERK Signaling, HIF-1α, and Catalase by Hyperoxia Exposure in Neonatal Rats
Therapeutic management that targets MAPK/ERK signaling, HIF-1α, or catalase may serve as a protective agent against hyperoxia-induced oxidative damage to neonatal proximal tubules. Expand
Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring
Results from this study help us better understand the long‐lasting impact of gestational hypoxia on kidney development and the increased risk of chronic kidney disease. Expand
Imaging, Analysing and Interpreting Branching Morphogenesis in the Developing Kidney.
  • K. Short, I. Smyth
  • Biology, Medicine
  • Results and problems in cell differentiation
  • 2017
This chapter discusses how the ureteric bud arises in the developing embryo, how it undergoes branching, how the can measure and study this process and finally the likely relevance that this process has for the understanding of congenital and acquired kidney disease. Expand
New insights into the role of HNF-1β in kidney (patho)physiology
Understanding of the molecular mechanisms upstream and downstream of HNF-1β may lead to the development of new therapeutic approaches in cystic kidney disease and other HNF1B-related renal diseases. Expand
Endothelial marker-expressing stromal cells are critical for kidney formation.
While lineage-tracing revealed that the renal cortical stroma gave rise to a small subset of endothelial progenitors, these Flk1-expressing stromal cells are critical for patterning the peritubular capillaries, loss of FlK1 in the renal stroma leads to nonautonomous-patterning defects in ureteric lineages. Expand
Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.
Evidence is presented for a novel molecular mechanism regulating the self-renewal of nephron progenitors and congenital nephrons endowment by the highly conserved miR-17~92 cluster, and it is shown that one member of the cluster is sufficient to repress Cftr expression in vitro and that perturbation of CftR activity in nephropsies results in impaired proliferation. Expand


Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice.
This study suggests that Crim1 is involved in endothelial maintenance and integrity and its loss contributes to a primary defect in the extraglomerular vasculature. Expand
Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling.
A link between gestational hypoxia and CAKUT is shown, the phenotype of which varies with timing, duration, and severity of the hypoxic insult. Expand
Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery.
It is demonstrated that calcineurin is an essential signaling molecule in urinary tract development and is required for normal proliferation of the urinary tract mesenchymal cells in a cell-autonomous manner. Expand
Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins
This model supports the involvement of endothelial cells/monocytes in fibrosis within the tubulointerstitium, but also the heterogeneity of the fibrotic process even within distinct regions of the same kidney. Expand
Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy.
The UUO model is likely to reveal useful biomarkers of progression of renal disease, as well as new therapies, which are desperately needed to allow intervention before the establishment of irreversible renal injury. Expand
Pod1 is required in stromal cells for glomerulogenesis
  • S. Cui, L. Schwartz, S. Quaggin
  • Biology, Medicine
  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2003
Histologic, immunohistochemical, and in situ hybridization analysis of the resulting chimeric offspring demonstrated both cell autonomous and non–cell autonomous roles for Pod1 in the differentiation of specific renal cell lineages that include peritubular interstitial cells and pericytes. Expand
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
The data suggest that diameter is established during early morphogenetic stages by convergent extension processes and maintained by polarized cell divisions, and Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes. Expand
Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice.
Results indicate that the loss of one GDNF allele results in reduced nephron endowment in the adult kidney, presumably as the result of reduced branching morphogenesis of the ureteric bud. Expand
Targeted inactivation of EGF receptor inhibits renal collecting duct development and function.
Results suggest that unlike other tyrosine kinases expressed at the UB tip, EGFR functions primarily to drive elongation of the emerging collecting ducts and to optimize urine-concentrating ability. Expand
Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice
Results highlight the previously unrecognized association between defects in papillary development and progression to chronic kidney disease later in life, as well as implicating Crim1 in Papillary extension and pelvic smooth muscle contractility. Expand