Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.

@article{Patchev1997NeonatalTO,
  title={Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.},
  author={Vladimir K. Patchev and Alexandra Montkowski and Daniela Rouskova and L{\'a}szl{\'o} Kor{\'a}nyi and Florian Holsboer and Osborne FX Almeida},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 5},
  pages={962-6}
}
Stressful experience during early brain development has been shown to produce profound alterations in several mechanisms of adaptation, while several signs of behavioral and neuroendocrine impairment resulting from neonatal exposure to stress resemble symptoms of dysregulation associated with major depression. This study demonstrates that when applied concomitantly with the stressful challenge, the steroid GABA(A) receptor agonist 3,21-dihydropregnan-20-one (tetrahydrodeoxycorticosterone, THDOC… CONTINUE READING

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