Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.

@article{Broek2016NeonatalTR,
  title={Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.},
  author={Theo van den Broek and Eveline M Delemarre and Willemijn J. M. Janssen and Rutger A. J. Nievelstein and Jasper C. Broen and Kiki Tesselaar and Jos{\'e} A. M. Borghans and Edward E. S. Nieuwenhuis and Berent Prakken and Michal Mokry and N J G Jansen and F Heidy van Wijk},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 3},
  pages={
          1126-36
        }
}
The generation of naive T cells is dependent on thymic output, but in adults, the naive T cell pool is primarily maintained by peripheral proliferation. Naive T cells have long been regarded as relatively quiescent cells; however, it was recently shown that IL-8 production is a signatory effector function of naive T cells, at least in newborns. How this functional signature relates to naive T cell dynamics and aging is unknown. Using a cohort of children and adolescents who underwent neonatal… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Immune tolerance . Regulatory T cells generated early in life play a distinct role in maintaining self - tolerance

O Alpdogan
  • Science .
  • 2015