Neonatal stress augments the hypoxic chemoreflex of adult male rats by increasing AMPA receptor-mediated modulation.

@article{Gulemetova2013NeonatalSA,
  title={Neonatal stress augments the hypoxic chemoreflex of adult male rats by increasing AMPA receptor-mediated modulation.},
  author={Roumiana Gulemetova and Guy Drolet and Richard Kinkead},
  journal={Experimental physiology},
  year={2013},
  volume={98 8},
  pages={
          1312-24
        }
}
Neonatal stress disrupts the developmental trajectory of homeostatic systems. Adult (8- to 10-week-old) male rats exposed to maternal separation (a form of neonatal stress) display several traits reported in patients suffering from sleep-disordered breathing, including an augmented hypoxic chemoreflex. To understand the mechanisms behind this effect, we tested the hypothesis that neonatal stress augments glutamatergic neurotransmission in three regions involved in respiratory regulation, namely… CONTINUE READING
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