Neonatal streptozotocin-induced diabetes mellitus: a model of insulin resistance associated with loss of adipose mass.

@article{Takada2007NeonatalSD,
  title={Neonatal streptozotocin-induced diabetes mellitus: a model of insulin resistance associated with loss of adipose mass.},
  author={Julie Takada and Magaly A Machado and Sidney Barnab{\'e} Peres and Luciana Catunda Brito and Cristina das Neves Borges-Silva and Cec{\'i}lia E M Costa and Miriam Helena Fonseca-Alaniz and Sandra Andreotti and Fabio H B Lima},
  journal={Metabolism: clinical and experimental},
  year={2007},
  volume={56 7},
  pages={977-84}
}
The use of experimental models of diabetes mellitus (DM) has been useful in understanding the complex pathogenesis of DM. Streptozotocin (STZ) injected in rats during the neonatal period has usually led to the major features described in diabetic patients (hyperglycemia, polyphagia, polydipsia, polyuria, and abnormal glucose tolerance) in a short period. Diabetes mellitus is a product of low insulin sensibility and pancreatic beta-cell dysfunction. Its process is characterized by a symptomless… CONTINUE READING

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