Neonatal stimulation of 5‐HT2 receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic area

@article{Dakin2008NeonatalSO,
  title={Neonatal stimulation of 5‐HT2 receptors reduces androgen receptor expression in the rat anteroventral periventricular nucleus and sexually dimorphic preoptic area},
  author={C. Dakin and C. Wilson and I. Kall{\'o} and C. Coen and D. Davies},
  journal={European Journal of Neuroscience},
  year={2008},
  volume={27}
}
  • C. Dakin, C. Wilson, +2 authors D. Davies
  • Published 2008
  • Biology, Medicine
  • European Journal of Neuroscience
  • Masculinization of the brain is dependent upon a perinatal surge in testosterone. It also requires a transient decrease in hypothalamic 5‐HT concentration and turnover and an increase in androgen receptor (AR) expression during the second postnatal week. We have previously shown that increasing 5‐HT activity over this period in male or androgenized female rats feminizes their adult behaviour and also feminizes the size of their anteroventral periventricular nucleus (AVPV) and sexually dimorphic… CONTINUE READING
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