Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL have congenital hypothyroidism.

Abstract

OBJECTIVES To determine the prevalence of congenital hypothyroidism in children with filter-paper blood-spot TSH (b-TSH) between 5 and 10μIU/mL in the neonatal screening. METHODS This was a retrospective study including children screened from 2003 to 2010, with b-TSH levels between 5 and 10μIU/mL, who were followed-up during the first two years of life when there was no serum TSH normalization. The diagnosis of congenital hypothyroidism was defined as serum TSH ≥10μIU/mL and start of levothyroxine treatment up to 2 years of age. RESULTS Of the 380,741 live births, 3713 (1.04%) had filter paper TSH levels between 5 and 10μIU/mL and, of these, 339 (9.13%) had congenital hypothyroidism. Of these, 76.11% of the cases were diagnosed in the first three months of life and 7.96% between 1 and 2 years of age. CONCLUSION The study showed that 9.13% of the children with b-TSH levels between 5 and 10μIU/mL developed hypothyroidism and that in approximately one-quarter of them, the diagnosis was confirmed only after the third month of life. Based on these findings, the authors suggest the use of a 5μIU/mL cutoff for b-TSH levels and long-term follow-up of infants whose serum TSH has not normalized to rule out congenital hypothyroidism.

DOI: 10.1016/j.jped.2017.05.003

Cite this paper

@article{ChristensenAdad2017NeonatalS9, title={Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL have congenital hypothyroidism.}, author={Fl{\'a}via Corr{\^e}a Christensen-Adad and Carolina Taddeo Mendes-Dos-Santos and Maura Mikie Fukujima Goto and Let{\'i}cia Esp{\'o}sito Sewaybricker and Lilia Freire Rodrigues D'Souza-Li and Gil Guerra-J{\'u}nior and Andr{\'e} Moreno Morcillo and Sofia Helena Valente de Lemos-Marini}, journal={Jornal de pediatria}, year={2017}, volume={93 6}, pages={649-654} }