Neonatal pulmonary oxygen toxicity in the rat and lung changes with aging.

@article{Thibeault1990NeonatalPO,
  title={Neonatal pulmonary oxygen toxicity in the rat and lung changes with aging.},
  author={Donald W. Thibeault and Sherry M. Mabry and M M Rezaiekhaligh},
  journal={Pediatric pulmonology},
  year={1990},
  volume={9 2},
  pages={96-108}
}
The aims of this study were to determine if neonatal hyperoxia exposure causes permanent lung damage and to define the relationship between neonatal lung oxygen toxicity and aging. Sprague-Dawley newborn rats (n = 85) breathed 100% oxygen (O2) or room air (RA) during the first 8 days of life, and then RA. At 2 and 22 months of age we assessed right ventricular (RV) systolic pressure (RVSP), RV weight, saline and air pressure-volume curves, volume density of lung parenchyma and nonparenchyma… CONTINUE READING

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