Neonatal programming of rat behavior by downregulation of alpha2A-adrenoreceptor gene expression in the brain.

Abstract

Short-term knockdown of alpha2A-adrenergic receptor gene expression in the rat brain by siRNA or antisense oligodeoxynucleotide during the first days of life induced acute and long-lasting neurochemical and behavioral alterations. The acute effects in the neonatal rats were consistent with the known functions of the alpha2A-adrenergic receptors in the… (More)
DOI: 10.1196/annals.1410.063

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