Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.

@article{AmosKroohs2011NeonatalMD,
  title={Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.},
  author={Robyn M. Amos-Kroohs and Michael T Williams and Charles V Vorhees},
  journal={Neuroscience letters},
  year={2011},
  volume={502 3},
  pages={152-6}
}
Methylphenidate (MPD) is the most prescribed drug for attention deficit hyperactivity disorder. Licit and illicit use also occurs during pregnancy, however the effects from this use on offspring development are unknown. To model late gestational exposure, Sprague-Dawley litters were treated with 0, 5, 10, 20, or 30mg/kg×4/day every 2h with MPD on postnatal days 11-20 (within-litter design; days chosen to be comparable to human third trimester brain development). During treatment, body weights… CONTINUE READING
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