Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat.

@article{Chung2007NeonatalMS,
  title={Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat.},
  author={Elaine K Y Chung and Xiao-jun Zhang and Zhi Li and Hongqi Zhang and Hong-Xi Xu and Zhaoxiang Bian},
  journal={Brain research},
  year={2007},
  volume={1153},
  pages={68-77}
}
Psychological stress experienced in early life plays an important role in the development of visceral hyperalgesia in irritable bowel syndrome (IBS). Neonatal maternal separation has been shown to trigger a long-term alternation in stress-induced responses to visceral nociceptive stimuli in rats. The aim of the present study was to show a direct evidence of stress-induced alteration in central neuronal responses to colorectal distention (CRD) in rats by a quantitative study of c-fos expression… CONTINUE READING

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