Neonatal lupus erythematosus: studies on HLA class II genes and autoantibody profiles in Japanese mothers.

Abstract

Neonatal lupus erythematosus (NLE) is a rare disorder of neonates characterized by two major clinical manifestations: congenital heart block and cutaneous lupus lesions. The disease is associated with placentally transferred maternal anti-Ro/SSA and/or La/SSB antibodies. To clarify possible class II HLA associations with maternal autoantibody responses… (More)

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