Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.

@article{Tybulewicz1991NeonatalLA,
  title={Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.},
  author={Victor L. J. Tybulewicz and Christopher Crawford and Peter Kent Jackson and Roderick Terry Bronson and Richard C. Mulligan},
  journal={Cell},
  year={1991},
  volume={65 7},
  pages={1153-63}
}
The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks… CONTINUE READING
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