Neonatal isolation changes the expression of IGF-IR and IGFBP-2 in the hippocampus in response to adulthood restraint stress.

@article{Erabi2007NeonatalIC,
  title={Neonatal isolation changes the expression of IGF-IR and IGFBP-2 in the hippocampus in response to adulthood restraint stress.},
  author={Kaori Erabi and Shigeru Morinobu and Ki-ichiro Kawano and Seiichi Tsuji and Shigeto Yamawaki},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 3},
  pages={369-81}
}
Early adverse experiences are thought to contribute to the development of stress vulnerability, and to increase the onset of stress-related psychiatric disorders in stressful environments in adulthood. One plausible molecular mechanism of stress vulnerability is the modulation of neurotrophic factor signal transduction in the hippocampus by early adversity. In the present study we investigated the influence of neonatal isolation (NI) with or without adulthood single restraint stress (SRS) on… CONTINUE READING

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