Neonatal innate immunity in allergy development.

  title={Neonatal innate immunity in allergy development.},
  author={Mirjam E. Belderbos and Ofer Levy and Louis J. Bont},
  journal={Current opinion in pediatrics},
  volume={21 6},
PURPOSE OF REVIEW The neonate is born with a distinct immune system that is biased against the production of T-helper cell 1 (Th1) cytokines. Birth imposes a great challenge on the neonatal immune system, which is confronted with an outside world rich in foreign antigens. Exposure to these antigens shapes the developing neonatal immune system. Inducing Th-1 or Th-2 polarized responses that may extend beyond the neonatal age and counteract or promote allergic sensitization. This review describes… CONTINUE READING
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