Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats

  • Jin Hwan Lee, Alyssa R. Espinera, +7 authors Shan Ping Yu
  • Published 2016 in Journal of Neuroinflammation


Autism spectrum disorder (ASD) affects many children and juveniles. The pathogenesis of ASD is not well understood. Environmental factors may play important roles in the development of ASD. We examined a possible relationship of inflammatory pain in neonates and the development of ASD in juveniles. Acute inflammation pain was induced by 5 % formalin (5 μl… (More)
DOI: 10.1186/s12974-016-0575-x