Neonatal imprinting of sex differences in the hepatic metabolism of a chlorinated cyclodiene by rat liver microsomes.


The effects of neonatal gonadectomy and the neonatal administration of steroid hormones on the development of sex differences in hepatic drug metabolism in the adult rat have been investigated. Castration of male rats at birth prevented the development of sex differences in metabolism in adult life. The effects of neonatal castration of male rats on the… (More)


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