Neonatal imprinting and regulation of estrogen receptor alpha and beta mRNA expression by estrogen in the pituitary and hypothalamus of the male rat.

@article{TenaSempere2001NeonatalIA,
  title={Neonatal imprinting and regulation of estrogen receptor alpha and beta mRNA expression by estrogen in the pituitary and hypothalamus of the male rat.},
  author={Manuel Tena-Sempere and Lucas C Gonzalez and Leonor Pinilla and I lpo Huhtaniemi and Enrique Aguilar},
  journal={Neuroendocrinology},
  year={2001},
  volume={73 1},
  pages={
          12-25
        }
}
In male rodents, complete reproductive function is critically dependent on adequate estrogen action at different levels of the hypothalamic-pituitary-testicular axis. However, administration of high doses of estrogen during the critical period of neonatal differentiation results in multiple defects in the reproductive axis that disrupt male fertility, the molecular mechanism(s) behind such a phenotype remaining poorly characterized. The aim of this study was twofold: (1) to characterize the… CONTINUE READING
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