Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells.

@article{Zaghouani2009NeonatalIF,
  title={Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells.},
  author={Habib Zaghouani and Christine M. Hoeman and Becky Adkins},
  journal={Trends in immunology},
  year={2009},
  volume={30 12},
  pages={585-91}
}
Immunity in the newborn is characterized by minimal T helper (Th)1 function but an excess of Th2 activity. Since Th1 lymphocytes are important to counter microbes and Th2 cells favor allergies, the newborn faces susceptibility to microbial infections and allergic reactions. Delayed maturation of certain dendritic cells leads to limited interleukin (IL)-12 production during the neonatal period. The Th2 cytokine locus of neonatal CD4(+) T cells is poised epigenetically for rapid and robust… CONTINUE READING
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