Neonatal hypoxic–ischemic injury increases forebrain subventricular zone neurogenesis in the mouse

@article{Plane2004NeonatalHI,
  title={Neonatal hypoxic–ischemic injury increases forebrain subventricular zone neurogenesis in the mouse},
  author={Jennifer M. Plane and Ruowen Liu and Tsu-Wei Wang and Faye Sarah Silverstein and Jack M. Parent},
  journal={Neurobiology of Disease},
  year={2004},
  volume={16},
  pages={585-595}
}
Neurogenesis persists throughout life in the rodent subventricular zone (SVZ)-olfactory bulb pathway and increases in the adult after brain insults. The influence of neonatal injury on SVZ neural precursors is unknown. We examined the effects of hypoxia-ischemia (HI) on neonatal mouse SVZ cell proliferation and neurogenesis. Postnatal day 10 (P10) mice underwent right carotid artery ligation followed by 10% O2 exposure for 45 min. The SVZ area and hemispheric injury were quantified… CONTINUE READING

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