Neonatal herpes simplex virus type 1 brain infection affects the development of sensorimotor gating in rats

@article{Engel2000NeonatalHS,
  title={Neonatal herpes simplex virus type 1 brain infection affects the development of sensorimotor gating in rats},
  author={J. Engel and J. Zhang and T. Bergstr{\"o}m and N. Conradi and L. Svensson},
  journal={Brain Research},
  year={2000},
  volume={863},
  pages={233-240}
}
The effect of neonatal brain infection of herpes simplex virus type 1 (HSV-1) on the development of sensorimotor function in the rat was investigated using an acoustic startle paradigm. Intracerebral inoculation of HSV-1 at day 2 after birth, but not at day 4, caused a significant delay in the development of prepulse inhibition of acoustic startle. A decrease in prepulse inhibition was shown at 37, 46 and 58 days of age in these rats compared to control rats. No evidence was obtained for other… Expand
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