Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis.

@article{Sharma2007NeonatalGB,
  title={Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis.},
  author={Renu Sharma and Joseph J. Tepas and Mark Lawrence Hudak and Daniel L Mollitt and Peter Wludyka and Ru-Jeng Teng and Bangalore R Premachandra},
  journal={Journal of pediatric surgery},
  year={2007},
  volume={42 3},
  pages={454-61}
}
BACKGROUND/PURPOSE Failure of the gut barrier and endotoxemia have been implicated in sepsis and multiple organ failure (MOF) syndromes in adults. The contributions of endotoxin (ETX) and proinflammatory cytokines (CKs) to the pathophysiology of disease and the outcomes of infants in the neonatal intensive care unit (NICU) are not clear. We measured ETX and CK concentrations in infants who presented with clinical signs of sepsis and/or necrotizing enterocolitis (NEC) to study their impact on… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis.

American journal of physiology. Gastrointestinal and liver physiology • 2012
View 13 Excerpts
Highly Influenced

Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis.

American journal of physiology. Gastrointestinal and liver physiology • 2009
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…