Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism

@article{Bouvattier2012NeonatalGT,
  title={Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism},
  author={Claire Bouvattier and Luigi Maione and J{\'e}r{\^o}me Bouligand and Catherine Dod{\'e} and Anne Guiochon‐Mantel and Jacques Young},
  journal={Nature Reviews Endocrinology},
  year={2012},
  volume={8},
  pages={172-182}
}
Congenital hypogonadotropic hypogonadism (CHH) causes pubertal failure and infertility in both women and men due to partial or total secretory failure of the two pituitary gonadotropins lutropin (LH) and follitropin (FSH) during periods of physiological activation of the gonadotropic axis. Men and women with CHH frequently seek treatment for infertility after hypogonadism therapy. Some etiologies, such as autosomal dominant or X-linked Kallmann syndrome, raise the question of hereditary… Expand
Male acquired hypogonadotropic hypogonadism: diagnosis and treatment.
TLDR
Postnatal AHH may prevent the onset of puberty or appear during pubertal development, but it usually emerges after the normal age of puberty, and symptoms, usually associated with significant testosterone deficiency in men with AHH, improve with testosterone replacement therapy. Expand
Approach to the male patient with congenital hypogonadotropic hypogonadism.
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  • The Journal of clinical endocrinology and metabolism
  • 2012
TLDR
The most likely differential diagnosis before age 18 yr is constitutional delay of puberty, and the choice of a particular hormone replacement therapy protocol aimed at virilizing the patient will depend on age at diagnosis and local practices. Expand
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TLDR
The impact of chronic gonadotropin deficiency on the endocrine functions of the interstitial compartment, which contains testosterone-, estradiol- and INSL3-secreting Leydig's cells, is discussed. Expand
Efficacy and Outcome Predictors of Gonadotropin Treatment for Male Congenital Hypogonadotropic Hypogonadism
TLDR
Gonadotropin therapy induces spermatogenesis in male CHH patients and a larger basal testicular size and noncryptorchidism history are favorable indicators for earlier sperMatogenesis. Expand
Clinical Management of Congenital Hypogonadotropic Hypogonadism.
TLDR
This review is a comprehensive synthesis of the current literature available regarding the diagnosis, patient management, and genetic foundations of CHH relative to normal reproductive development. Expand
European Consensus Statement on congenital hypogonadotropic hypogonadism— pathogenesis, diagnosis and treatment
| Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which is the master hormoneExpand
Hormonal control of spermatogenesis in men: therapeutic aspects in hypogonadotropic hypogonadism.
TLDR
A large, multicenter clinical trial is needed to definitively prove the optimal treatment approach for severe CHH, as a randomized, open label treatment study addressed the question whether a sequential treatment with FSH alone prior to LH and FSH (via GnRH pump) could enhance fertility outcomes. Expand
Gonadotrophin replacement for induction of fertility in hypogonadal men.
TLDR
Historical and recent literature is reviewed to summarize the current evidence on therapeutic approaches for CHH men seeking fertility and to recommend approaches to optimize fertility outcomes in severely affected CHH patients. Expand
Congenital Hypogonadotropic Hypogonadism (Isolated GnRH Deficiency)
TLDR
In this chapter, the pathogenesis, clinical manifestation, diagnosis, and treatment of CHH is discussed and mutations in more than 25 genes are identified. Expand
Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism
TLDR
Genetic testing identified a de novo, heterozygous mutation in fibroblast growth factor receptor 1 (FGFR1 p.L630P) that confirms the diagnosis of CHH, allowing for a timely hormonal treatment to induce pubertal development. Expand
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