Neonatal exposure to the glutamate receptor antagonist MK-801: Effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats

Abstract

Neonatal lesions of the ventral hippocampus in rats lead to post- but not pre-pubertal behavioural changes suggesting adolescent onset of dopaninergic hypersensitivity and providing an animal model of schizophrenia. Neonatal exposure to glutamate receptor antogonists produces accelerated apoptosis leading to neuronal loss in central nervous system… (More)
DOI: 10.1080/10298420290031414

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