Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat.

@article{Bhardwaj2012NeonatalET,
  title={Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat.},
  author={Sanjeev K. Bhardwaj and Patrick A Forcelli and Guillermo A Palchik and Karen N Gale and Lalit K. Srivastava and Alexei D Kondratyev},
  journal={Neuropharmacology},
  year={2012},
  volume={62 7},
  pages={2337-45}
}
Previous work has indicated an association between seizures early in life and increased risk of psychiatric disorders, including schizophrenia. However, because early-life seizures are commonly treated with antiepileptic drugs (AEDs) such as phenobarbital, the possibility that drug treatment may affect later-life psychiatric outcomes needs to be evaluated. We therefore tested the hypothesis that phenobarbital exposure in the neonatal rat increases the risk of schizophrenia-like behavioral… CONTINUE READING

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