Neonatal exposure to estradiol induces resistance to helminth infection and changes in the expression of sex steroid hormone receptors in the brain and spleen in adult mice of both sexes.

@article{Guzmn2009NeonatalET,
  title={Neonatal exposure to estradiol induces resistance to helminth infection and changes in the expression of sex steroid hormone receptors in the brain and spleen in adult mice of both sexes.},
  author={Carolina Guzm{\'a}n and Ignacio Camacho-Arroyo and Marco A De Le{\'o}n-Nava and Jorge Morales-Montor},
  journal={Brain, behavior, and immunity},
  year={2009},
  volume={23 5},
  pages={709-15}
}
A single injection of 17beta-estradiol administered to 4-day-old male and female mice increased the cellular immune response, and induced resistance to Taenia crassiceps cysticercosis as well as changes in the expression pattern of progesterone (PR) and estrogen receptor (ER) isoforms in the brain and splenocytes. Regardless of gender, when treated mice reached adulthood, they were highly resistant to infection. Female mice presented early vaginal opening and altered estrous cycles. In male and… CONTINUE READING