Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

@article{Lipska1995NeonatalEH,
  title={Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine},
  author={Barbara K. Lipska and Daniel R. Weinberger and Neal R. Swerdlow and Mark A. Geyer and David L. Braff and George E. Jaskiw},
  journal={Psychopharmacology},
  year={1995},
  volume={122},
  pages={35-43}
}
Neonatal excitotoxic hippocampal damage in the rat results in postpubertal onset of a variety of abnormal behaviors related to excessive dopaminergic transmission in the mesolimbic/nigrostriatal system, and thus may be considered an animal model of some aspects of schizophrenia. Because sensorimotor gating is impaired in adult patients with schizophrenia… CONTINUE READING