Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats

@article{Heroux2018NeonatalEE,
  title={Neonatal ethanol exposure impairs long-term context memory formation and prefrontal immediate early gene expression in adolescent rats},
  author={Nicholas A Heroux and Patrese A Robinson-Drummer and Malak Kawan and Jeffrey B Rosen and Mark E Stanton},
  journal={Behavioural Brain Research},
  year={2018},
  volume={359},
  pages={386-395}
}
Fetal alcohol exposure leads to severe disruptions in learning and memory involving the hippocampus and prefrontal cortex in humans. Animal model research on FASD has documented impairment of hippocampal neuroanatomy and function but animal studies of cognition involving the prefrontal cortex are sparse. We have found that a variant of contextual fear conditioning in which both the hippocampus and prefrontal cortex is required, the Context Preexposure Facilitation Effect (CPFE), is particularly… CONTINUE READING

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