Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats

@article{Hilakivi1987NeonatalDO,
  title={Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats},
  author={Leena A. Hilakivi and D. E. Stenberg and John David Sinclair and Kalervo Kiianmaa},
  journal={Psychopharmacology},
  year={1987},
  volume={91},
  pages={403-409}
}
To study the relationship between neonatal antidepressant administration, active (REM) sleep and adult alcohol-related behavior, rat pups were treated daily with 5 mg/kg despramine (DMI) or 25 mg/kg zimeldine SC from the 6th to the 19th postnatal days. Movement sensitive mattress (“SCSB”) measurements showed that zimeldine treatment suppressed active sleep throughout the whole treatment period, but DMI was more effective during the first 8 days than during the last treatment days. At the age of… CONTINUE READING