Neonatal corticosteroid permanently alters brain activity of epinephrine-synthesizing enzyme in stressed rats.

Abstract

The enzyme responsible for the conversion of norepinephrine to epinephrine, phenylethanolamine N-methyltransferase (PNMT; E. C. 2.1.1.28), is present in the adrenal medulla 1, other chromaffin tissues, sympathetic ganglia 4, and the central nervous systemlL Immunofluorescence and radioenzymatic assays have localized PNMT in discrete brain regions including… (More)

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