Neonatal clonidine treatment results in long-lasting changes in noradrenaline sensitivity and kindling epileptogenesis.

Abstract

In the present experiment we tested the hypothesis that early interference with noradrenaline transmission can have permanent consequences for brain function in adulthood. Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal CA1 cells as shown in our previous… (More)

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@article{Gorter1990NeonatalCT, title={Neonatal clonidine treatment results in long-lasting changes in noradrenaline sensitivity and kindling epileptogenesis.}, author={Jan A. Gorter and Willem Kamphuis and Evelien Huisman and Nico Bos and Majid Mirmiran}, journal={Brain research}, year={1990}, volume={535 1}, pages={62-6} }