Neonatal cerebral hypoxia-ischemia: The effect of adenosine receptor antagonists

@article{Bona1997NeonatalCH,
  title={Neonatal cerebral hypoxia-ischemia: The effect of adenosine receptor antagonists},
  author={Elsa Bona and Ulrika {\AA}d{\'e}n and Eric Gilland and Bertil B. Fredholm and Henrik H Hagberg},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={1327-1338}
}
The effects of nonselective (theophylline), A1-(DPCPX) or A2A-selective (SCH 58261) adenosine receptor antagonists administered before or after neonatal hypoxia-ischemia (HI) were studied on the extent of brain injury in 7-day-old rats evaluated after 14 days. A possible effect of theophylline (20 mg/kg) on expression of immediate early genes was studied with in situ hybridization. Theophylline (20, 30 or 60 mg/kg) given prior to HI reduced brain damage by 48% (P < 0.001), 36% (P < 0.01) and 34… CONTINUE READING
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