Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion.

@article{Karlsson1992NeonatalCI,
  title={Neonatal capsaicin-treatment in mice: effects on pancreatic peptidergic nerves and 2-deoxy-D-glucose-induced insulin and glucagon secretion.},
  author={Sven Karlsson and Frank Sundler and Bo Ahr{\'e}n},
  journal={Journal of the autonomic nervous system},
  year={1992},
  volume={39 1},
  pages={
          51-9
        }
}
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43 Citations
Highly Influential Citations
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Background Citations
15
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2
Results Citations
1

43 Citations

Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test.

Involvement of capsaicin-sensitive nerves in the regulation of glucose tolerance in diabetic rats.

Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice.

  • B. Ahrén
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2004
It is concluded that GLP-1-induced insulin secretion at a low dose in mice is dependent on intact sensory nerves and therefore indirectly mediated and that this distinguishes GLP -1 from other examined insulin secretagogues.

University of Groningen Ablation of capsaicin-sensitive afferent nerves affects insulin response during an intravenous glucose tolerance test

It is hypothesized that sensory afferents could play a role in the aetiology of pathologies where glucohomeostatic mechanisms are disturbed, as is in type 2 diabetes mellitus, and it is suggested that capsaicin-sensitive nerves could be involved in the regulation of insulin sensitivity.

Involvement of capsaicin-sensitive nerves in regulating the hormone and glucose metabolic response to endotoxin.

Data indicate that sensory afferent neurons play a critical role in the early secretory response of glucagon and catecholamines, the maintenance of tissuecatecholamine responsiveness, and the stimulation of glucose production after LPS.

The role of CGRP and afferent nerves in the modulation of pancreatic enzyme secretion in the rat

  • J. JaworekS. KonturekA. Szlachcic
  • Biology, Medicine
    International journal of pancreatology : official journal of the International Association of Pancreatology
  • 1997
Stimulation of pancreatic sensory nerves by capsaicin produced secretory effects probably caused, at least in part, by the release of CGRP, which increased enzyme secretion, and this secretion was abolished by previous inactivation of sensory nerve by this neurotoxin.

Influence of the neurotoxin capsaicin on rat pancreatic islets in culture, and on the pancreatic islet blood flow of rats.

Insulin secretion by gastrin-releasing peptide in mice: ganglionic versus direct islet effect.

It is concluded that the insulinotropic effect of GRP in the mouse is mediated by both direct islet effects and through activation, at the ganglionic level, of postganglionic cholinergic nerves.

Insulin secretion by gastrin-releasing peptide in mice: ganglionic versus direct islet effect.

It is concluded that the insulinotropic effect of GRP in the mouse is mediated by both direct islet effects and through activation, at the ganglionic level, of postganglionic cholinergic nerves.

Pancreatic endocrine responses to substance P and calcitonin gene-related peptide in conscious calves.

The results suggest that SP and CGRP may modulate the secretion of PP and glucagon in the normal conscious calf but not that of insulin, and it is also possible that SP modulates secretion of pancreatic glucagons in these animals.

References

SHOWING 1-10 OF 28 REFERENCES

Effect of capsaicin‐sensitive sensory nerves on plasma glucose and catecholamine levels during 2‐deoxyglucose‐induced stress in conscious rats

The results indicate that capsaicin‐sensitive sensory fibres are not required to maintain adrenal CA secretion during glucopenic stress in the conscious rat but are required for maintenance of blood glucose levels.

Capsaicin-sensitive nerves are required for glucostasis but not for catecholamine output during hypoglycemia in rats.

Somaostatin and SMS-(201-995), a somatostatin analogue, both potentiated and prolonged the insulin-induced hypoglycemia, resulting in an increase in circulating CA levels that was suppressed by hexamethonium and atropine.

Inhibition of 2-deoxy-glucose-induced glucagon secretion by muscarinic and alpha-adrenoceptor blockade in the mouse.

Calcitonin gene-related peptide: occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse.

It is concluded that CGRP occurs in islet cells and in intrapancreatic nerve fibers of both the mouse and the rat, and inhibits both basal and stimulated insulin secretion in vivo in the mouse.

Galanin release during pancreatic nerve stimulation is sufficient to influence islet function.

The effect of MPNS on IRI, SLI, and IRG output was compared with the effect of synthetic galanin infused directly into the pancreatic artery at a rate that reproduced the MPNS-induced spillover of GLIR, which was nearly identical to the increment produced by MPNS.

Sensory substance P innervation of the stomach and pancreas: Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing

Evidence for noncholinergic ganglionic neural stimulation of B cell secretion.

The above data suggests that 1) the insulin rise post-2DG is beta-adrenergic but 2) the ganglionic neurotransmitter mediating the 2DG-induced insulin rise duringganglionic blockade is noncholinergic (possibly peptidergic).

Immunocytochemical identification of islet cells and nerve fibers containing calcitonin gene-related peptide-like immunoreactivity in the rat pancreas.

Pancreatic neuroendocrinology: peripheral neural mechanisms in the regulation of the Islets of Langerhans.

  • R. Miller
  • Medicine, Biology
    Endocrine reviews
  • 1981
The anatomy of the islet in relation to its vascular supply and both motor and sensory autonomic nerves, which may play a role in altering the secretion rate of islet hormones are described.

The permanent anatomical effects of neonatal capsaicin on somatosensory nerves.

It is concluded that neonatal capsaicin produces selective degeneration of unmyelinated axons in the neonatal period which has effectively reached its full extent by early adult life.