Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats.

@article{Kannampalli2017NeonatalBI,
  title={Neonatal bladder inflammation induces long-term visceral pain and altered responses of spinal neurons in adult rats.},
  author={Pradeep Kannampalli and Reji Babygirija and Jian Zhang and Michael M. Poe and Guanguan Li and James M Cook and Reza Shaker and Banani Banerjee and Jyoti N. Sengupta},
  journal={Neuroscience},
  year={2017},
  volume={346},
  pages={349-364}
}
Painful events early in life have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. However, the intrinsic mechanism is not well studied. We previously reported that neonatal bladder inflammation causes chronic visceral hypersensitivity along with molecular disruption of spinal GABAergic system in rats. The… CONTINUE READING