Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair

  title={Neonatal and Adult Cardiovascular Pathophysiological Remodeling and Repair},
  author={R. Norris and T. Borg and J. Butcher and T. Baudino and I. Banerjee and R. Markwald},
  journal={Annals of the New York Academy of Sciences},
  • R. Norris, T. Borg, +3 authors R. Markwald
  • Published 2008
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • The neonatal heart undergoes normal hypertrophy or compensation to complete development and adapt to increased systolic pressures. Hypertrophy and increased neonatal wall stiffness are associated with a doubling of the number of fibroblasts and de novo formation of collagen. Normal postnatal remodeling is completed within 3–4 weeks after birth but can be rekindled in adult life in response to environmental signals that lead to pathological hypertrophy, fibrosis, and heart failure. The signals… CONTINUE READING
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