Neonatal alloimmune thrombocytopenia due to anti-HPA 1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn.

@article{Jaegtvik2000NeonatalAT,
  title={Neonatal alloimmune thrombocytopenia due to anti-HPA 1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn.},
  author={Sissel Jaegtvik and Anne Husebekk and Berit Aune and P{\aa}l Oian and Lauritz Bredrup Dahl and Bj\orn R Skogen},
  journal={BJOG : an international journal of obstetrics and gynaecology},
  year={2000},
  volume={107 5},
  pages={691-4}
}
Eleven thousand one hundred pregnant women were genotyped for human platelet antigen HPA 1, and 198 HPA 1bb women were followed in the pregnancy with quantitative assay for anti-HPA la antibodies. Antibodies were detected in 24 women, and nine children were born with severe thrombocytopenia (< 50x10(9)/L). All mothers with high levels of antibodies were delivered of children with severe thrombocytopenia. None of the newborn infants had clinical signs of intra-cranial haemorrhage. The level of… CONTINUE READING
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