Neonatal alloimmune neutropenia attributed to maternal immunoglobulin G antibodies against the neutrophil alloantigen HNA-1c (SH): a report of five cases.

@article{Curtis2005NeonatalAN,
  title={Neonatal alloimmune neutropenia attributed to maternal immunoglobulin G antibodies against the neutrophil alloantigen HNA-1c (SH): a report of five cases.},
  author={Brian R Curtis and Corey Reno and Richard H Aster},
  journal={Transfusion},
  year={2005},
  volume={45 8},
  pages={1308-13}
}
BACKGROUND Neonatal alloimmune neutropenia (NAN) occurs when maternal immunoglobulin G (IgG) antibodies enter fetal circulation and destroy neonatal neutrophils. Whether antibodies specific for the neutrophil antigen HNA-1c (SH) can cause NAN is uncertain, because in three of four reported cases, other neutrophil-specific antibodies were present. In this report, we describe five cases of NAN, in which only anti-HNA-1c was detected in maternal serum. STUDY DESIGN AND METHODS HNA-1c antibodies… CONTINUE READING

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