Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity.

@article{Zhang2017NeonatalMD,
  title={Neonatal Maternal Deprivation Enhances Presynaptic P2X7 Receptor Transmission in Insular Cortex in an Adult Rat Model of Visceral Hypersensitivity.},
  author={Ping-An Zhang and Q Xu and Lu Xue and Hang Zheng and Jun Jun Yan and Ying Xiao and Guang-Yin Xu},
  journal={CNS neuroscience & therapeutics},
  year={2017},
  volume={23 2},
  pages={145-154}
}
AIMS Insular cortex (IC) is involved in processing the information of pain. The aim of this study was to investigate roles and mechanisms of P2X7 receptors (P2X7Rs) in IC in development of visceral hypersensitivity of adult rats with neonatal maternal deprivation (NMD). METHODS Visceral hypersensitivity was quantified by abdominal withdrawal reflex threshold to colorectal distension (CRD). Expression of P2X7Rs was determined by qPCR and Western blot. Synaptic transmission in IC was recorded… CONTINUE READING
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