Neonatal IgE: a poor screen for atopic disease.

  title={Neonatal IgE: a poor screen for atopic disease.},
  author={Rachel Ruiz and David Richards and David M Kemeny and Jack Price},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={21 4},
Screening for atopic disease using neonatal serum IgE has been advocated on the basis of the predictive value of elevated levels. However, this is only one measure of validity. The test was validated fully in 92 infants with a bi-parental history of atopy using 0.7 IU/ml as the cut-off. All infants were assessed prospectively for evidence of atopic disease (eczema, recurrent wheezing or food reactions) and skin-prick test positivity in the first year. Total serum IgE was measured by… CONTINUE READING

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