Neonatal Hyperoxia Exposure Induces Kidney Fibrosis in Rats.

  title={Neonatal Hyperoxia Exposure Induces Kidney Fibrosis in Rats.},
  author={Jianbao Jiang and Hsiu-Chu Chou and Tsu-fu Yeh and Chung-Ming Chen},
  journal={Pediatrics and neonatology},
  volume={56 4},
BACKGROUND Human and animal studies have demonstrated that neonatal hyperoxia increases oxidative stress and adversely affects glomerular and tubular maturity. This study was undertaken to determine how exposure to neonatal hyperoxia affected kidney morphology and fibrosis and to elucidate the relationship between connective tissue growth factor (CTGF) and collagen expression in rat kidneys. METHODS Sprague-Dawley rat pups were exposed to either hyperoxia or ambient air. The control groups… CONTINUE READING