Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.

@article{Yoshida2006NeonatalFR,
  title={Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.},
  author={Masaru Yoshida and Kanna Kobayashi and Timothy T. Kuo and Lynn Bry and Jonathan N Glickman and Steven M Claypool and Arthur Kaser and Takashi Nagaishi and Darren E. Higgins and Emiko Mizoguchi and Yoshio Wakatsuki and Derry Charles Roopenian and Atsushi Mizoguchi and Wayne I Lencer and Richard S Blumberg},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 8},
  pages={2142-2151}
}
The neonatal Fc receptor for IgG (FcRn) plays a major role in regulating host IgG levels and transporting IgG and associated antigens across polarized epithelial barriers. Selective expression of FcRn in the epithelium is shown here to be associated with secretion of IgG into the lumen that allows for defense against an epithelium-associated pathogen (Citrobacter rodentium). This pathway of host resistance to a bacterial pathogen as mediated by FcRn involves retrieval of bacterial antigens from… CONTINUE READING

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