Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model.

@article{Patel2011NeonatalFR,
  title={Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model.},
  author={Dipesh A. Patel and Alberto Puig-Canto and Dilip Kumar Challa and H{\'e}ctor Perez Montoyo and Raimund J. Ober and E Sally Ward},
  journal={Journal of immunology},
  year={2011},
  volume={187 2},
  pages={1015-22}
}
Multiple autoimmune diseases are characterized by the involvement of autoreactive Abs in pathogenesis. Problems associated with existing therapeutics such as the delivery of intravenous immunoglobulin have led to interest in developing alternative approaches using recombinant or synthetic methods. Toward this aim, in the current study, we demonstrate that the use of Fc-engineered Abs (Abs that enhance IgG degradation [Abdegs]) to block neonatal FcR (FcRn) through high-affinity, Fc region… CONTINUE READING