Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells.

@article{Akko2010NeonatalBV,
  title={Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells.},
  author={Tunç Akkoç and Metin Aydoğan and Aysegul Yildiz and Elif Karakoc-Aydiner and Aarif O Eifan and Sevgi Keles and Mustafa Seref Akin and Sultan Kavuncuoğlu and Nerin Nadir Bahçeciler and Isil Berat Barlan},
  journal={Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology},
  year={2010},
  volume={21 7},
  pages={
          1059-63
        }
}
To determine the optimal time of Bacillus Calmette-Guerin (BCG) vaccination for induction of Th1 immunity, we measured the interferon (IFN)-γ and interleukin (IL)-10 secretion in purified protein derivative (PPD)-stimulated peripheral blood mononuclear cell (PBMC) cultures in newborns vaccinated at birth or 2nd month of life. Moreover, role of CD4(+) CD25(+) T cells was studied by depletion assay at 8th month. Nineteen term and healthy newborns were randomized into two groups: Group I composed… CONTINUE READING
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