Neomycin-sorbitol and lactulose in the treatment of acute portal-systemic encephalopathy

@article{Atterbury1978NeomycinsorbitolAL,
  title={Neomycin-sorbitol and lactulose in the treatment of acute portal-systemic encephalopathy},
  author={Colin E. Atterbury and Willis C. Maddrey and Dr. Harold O. Conn},
  journal={The American Journal of Digestive Diseases},
  year={1978},
  volume={23},
  pages={398-406}
}
In a double-blind, randomized study the efficacy of lactulose was compared with neomycin-sorbitol in 45 episodes of acute nitrogenous portal-systemic encephalopathy (PSE) induced by dietary protein, azotemia, or gastrointestinal hemorrhage. All patients had underlying cirrhosis, and at the time of randomization had encephalopathy of at least grade 2 severity and arterial ammonia concentrations greater than 150 μg/100 ml. Two thirds of the patients in each group returned to normal mental status… CONTINUE READING
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Highly Influential
6 Excerpts

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