Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor.

@article{Pullan1992NeomycinIA,
  title={Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor.},
  author={L. M. Pullan and R J Stumpo and R J Powel and Kathy Paschetto and Michael Britt},
  journal={Journal of neurochemistry},
  year={1992},
  volume={59 6},
  pages={2087-93}
}
Neomycin appears as a full agonist and spermidine as a partial agonist at the site where polyamines enhance 1-[1-(2-thienyl)cyclohexyl][3H]piperidine ([3H]TCP) binding on the N-methyl-D-aspartate (NMDA) receptor. Other aminoglycosides also enhance [3H]TCP binding with efficacies roughly proportional to the number of primary amine groups. The polyamine antagonists ifenprodil and arcaine inhibit enhancement of [3H]TCP binding by spermidine or neomycin. The inhibition of [3H]TCP binding by arcaine… CONTINUE READING

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Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors.

The Journal of pharmacology and experimental therapeutics • 1999
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