Neomycin and spermine have similar effects on secretion and phosphoinositide metabolism in ATP-depleted permeabilized adrenal chromaffin cells.

@article{Cooper1993NeomycinAS,
  title={Neomycin and spermine have similar effects on secretion and phosphoinositide metabolism in ATP-depleted permeabilized adrenal chromaffin cells.},
  author={Cynthia Lynn Cooper and Ronald W Holz},
  journal={Biochemical and biophysical research communications},
  year={1993},
  volume={194 3},
  pages={
          1135-42
        }
}
To evaluate the requirement of bovine adrenal chromaffin cells for inositol phospholipids in secretion, the effects of neomycin and spermine on secretion and phosphoinositide metabolism were compared. Spermine and neomycin had virtually identical effects on secretion and phosphoinositide levels. Both polyamines 1) partially maintained secretion when added to permeabilized cells in the absence of ATP, 2) had no effect when added to cells in the presence of ATP and 3) inhibited secretion when… CONTINUE READING
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