Neomycin and Paromomycin Inhibit 30S Ribosomal Subunit Assembly in Staphylococcus aureus

@article{Mehta2003NeomycinA,
  title={
Neomycin and Paromomycin Inhibit 30S Ribosomal Subunit Assembly in Staphylococcus aureus},
  author={Roopal Mehta and W. Scott Champney},
  journal={Current Microbiology},
  year={2003},
  volume={47},
  pages={0237-0243}
}
A number of different antibiotics that prevent translation by binding to the 50S ribosomal subunit of bacterial cells have recently been shown to also prevent assembly of this subunit. Antibacterial agents affecting 30S particle activities have not been examined extensively for effects on small subunit formation. The aminoglycoside antibiotics paromomycin and neomycin bind specifically to the 30S ribosomal subunit and inhibit translation. These drugs were examined in Staphylococcus aureus cells… 

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Three methods to assay inhibitors of ribosomal subunit assembly.

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